Platelets Disappear Overnight: A Case Report of Vancomycin-Induced Immune Thrombocytopenia

While vancomycin-induced thrombocytopenia (VITP) is typically characterized by gradual platelet decline and recovery, more rapid and severe reexposure presentations remain poorly described in the literature. This case describes a 70-year-old woman with no known history of vancomycin exposure or thrombocytopenia who presented for cellulitis, was treated with vancomycin, and experienced a 99% reduction in platelet count overnight, as well as a transient symptomatic reaction of rigors and hypotension. Herein, we aim to increase awareness of this rarer form of VITP by presenting this case and recounting the previously established literature on VITP as a whole.