This model demonstrates enhanced STAT3 activation affecting scleral MMP-2/TIMP-2 balance in myopia, suggesting further investigation is needed.
During LIM development, STAT3 activation is enhanced in the retina, choroid, and sclera, with disrupted scleral MMP-2/TIMP-2 balance. These changes may correlate with myopia-related phenotypes (e.g. axial elongation, scleral remodeling), though their specific mechanism(s) remain to be elucidated.
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Zhao et al. (2026) studied this question.
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