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March 6, 2026RSC Chemical Biology0 citationsOpen Access

Comparative Analysis of Alkyne and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling

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DHDaphne van den HombergGPGeorgia PoulladofonouRadboud University NijmegenADAurelia DekensRadboud University Nijmegen

Key Points

  • The research aims to analyze the effectiveness of alkyne and desthiobiotinylated photoaffinity probes for profiling small molecule-RNA interactions.
  • Comparative analysis of alkyne and desthiobiotinylated photoaffinity probes
  • Application of chemotranscriptomic profiling techniques
  • Evaluation of interaction strength and specificity
  • Both probes demonstrated unique interaction patterns with RNA
  • Alkyne probes showed stronger binding affinity
  • Desthiobiotinylated probes offered broader specificity in interactions

Abstract

Understanding small molecule-RNA interactions is a crucial part in drug development and fundamental biology. Chemotranscriptomic profiling is emerging as a powerful platform to interrogate interactions of small molecules with entire...

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Cite This Study

Homberg et al. (2025) studied this question.

synapsesocial.com/papers/69aa7066531e4c4a9ff5a362https://doi.org/10.1039/d6cb00030d
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