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March 6, 2026JAMA Psychiatry5 citations

Integrating Physical Activity Into Routine Psychiatric Care

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BSBrendon StubbsRMRuimin MaMTMegan Teychenne

Key Result

Structured physical activity produces moderate to large reductions in depressive and psychotic symptoms and improves cardiometabolic health in adults with severe mental illness.

Key Points

  • This research aims to explore the integration of physical activity into routine psychiatric care to improve health outcomes in individuals with severe mental illness.
  • Identified the prevalence of low physical activity and high sedentary behavior in adults with severe mental illness.
  • Outlined the 5A framework for clinicians to integrate physical activity into care.
  • Reviewed recent meta-analyses on the effects of structured physical activity on psychiatric symptoms.
  • Structured physical activity significantly reduces depressive and psychotic symptoms.
  • Older adults with severe mental illness typically engage in over 10 hours of sedentary behavior daily.
  • Targeted interventions, like individualized exercise recommendations, lead to improved mental and physical health outcomes.

Structured PICO

P
Population
Adults with severe mental illness (SMI)
I
Intervention
Physical activity (PA) and reduction of sedentary behavior integrated into routine psychiatric care using the 5A framework

Systematically promoting physical activity and reducing sedentary behavior through structured clinical frameworks can improve symptoms and cardiometabolic health in people with severe mental illness.

Abstract

Importance Adults with severe mental illness (SMI) face a 10- to 20-year reduction in life expectancy, largely due to heightened cardiometabolic diseases. Low levels of physical activity (PA) and prolonged sedentary behavior (SB) are modifiable risk factors that contribute to this mortality gap. Although strong evidence demonstrates that PA is safe and effective in improving psychiatric and physical outcomes, systematic integration into clinical practice remains limited. Observations Individuals with SMI are among the most physically inactive groups in society, often spending more than 10 hours per day sedentary and rarely meeting recommended PA recommendations. Low PA and high SB exacerbate neuroinflammatory, neuroendocrine, and cardiometabolic pathways implicated in psychiatric morbidity. Recent meta-analyses show that structured PA, that is, exercise, produces moderate to large reductions in depressive and psychotic symptoms, as well as benefits for cognition, quality of life, and cardiometabolic health. Evidence also suggests that mentally passive SB, such as prolonged television viewing, are associated with poorer mental health outcomes. Physical activity should be individualized to each person’s capabilities and preferences, emphasizing forms they find enjoyable. Two sessions of strength training weekly are advised, and greater mental health benefits typically arise from leisure or active travel PA. To guide translation into care, the 5A framework (Ask, Assess, Advise, Assist, Arrange) provides a structured, pragmatic approach: clinicians can screen for PA and SB, assess readiness and safety, provide tailored advice, support motivation and goal setting, and arrange follow-up, referral, and community support. Conclusions and Relevance PA should be considered a core component of psychiatric care. By systematically promoting PA and reducing prolonged SB through structured clinical frameworks, psychiatrists and other mental health professionals can improve symptoms, enhance physical and cognitive health, and help narrow the life expectancy gap experienced by people with SMI.

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Cite This Study

Stubbs et al. (2026) studied this question. Structured physical activity produces moderate to large reductions in depressive and psychotic symptoms and improves cardiometabolic health in adults with severe mental illness.

synapsesocial.com/papers/69aa7077531e4c4a9ff5a480https://doi.org/10.1001/jamapsychiatry.2026.0026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1International Organization of Physical Therapy in Mental Health consensus on physical activity within multidisciplinary rehabilitation programmes for minimising cardio-metabolic risk in patients with schizophrenia2011 · 127 citations
  2. 2Physical activity reduces cardiovascular risk and mortality in people with severe mental illness: a cohort study using accelerometry2024
  3. 3A randomised controlled trial of interventions to promote adoption of physical activity in adults with severe mental illness2024 · 3 citations
  4. 4Physical activity targeting patients admitted to a psychiatric hospital– a mixed method feasibility study2025
  5. 5Association of Accelerometer‐Derived Physical Activity with Incident Cardiovascular Diseases and Mortality in People With Severe Mental Illness2026