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March 6, 2026Organic & Biomolecular Chemistry0 citationsOpen Access

Transaminase-Triggered Synthesis of 2,5-Disubstituted Pyrrolidines

AMAoife MartinUniversity College DublinLKLisa KennedyUniversity College DublinISIshita SolankiUniversity College Dublin

Key Points

  • The study aims to develop a method for synthesizing 2,5-disubstituted pyrrolidines using transaminases.
  • Utilized ketoenone substrates for synthesis
  • Employed a transaminase-triggered intramolecular aza-Michael reaction
  • Collected products as mixtures of diastereoisomers
  • Achieved moderate to good yields of pyrrolidines
  • Isolated pyrrolidines composed of diastereoisomers
  • Noted occurrence of novel epimerisation during the process

Abstract

2,5-Disubstituted pyrrolidines were synthesised from ketoenone substrates using a transaminase-triggered intramolecular aza-Michael reaction in moderate to good yields. The pyrrolidines were isolated as mixtures of diastereoisomers and a novel epimerisation...

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Cite This Study

Martin et al. (2025) studied this question.

synapsesocial.com/papers/69aa7096531e4c4a9ff5a7d9https://doi.org/10.1039/d6ob00264a
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