Roux-en-Y gastric bypass reduced BMI from 40.35 to 25.36 kg/m² and specific multivitamin supplementation increased vitamin D by 39 versus 23 nmol/L, vitamin B12 by 108 versus 9 pg/mL, and zinc by 3.7 versus -7.6 µg/dL at one year.
Observational (n=101)
No
Does RYGB-specific multivitamin supplementation improve serum micronutrient levels compared to other supplements in patients after Roux-en-Y gastric bypass?
RYGB-specific multivitamin supplementation leads to significantly better micronutrient profiles (vitamin D, B12, zinc) compared to standard supplements in the first year post-surgery.
Effect estimate: BMI decreased significantly (p < 0.001)
Absolute Event Rate: 25.36% vs 40.35%
p-value: p=<0.001
Background: Obesity is characterized by an abnormal or excessive accumulation of body fat that can be harmful to health 1. Bariatric surgery is effective for weight loss and improvement of comorbidities but carries a high risk of nutritional deficiencies 2-9. Objectives: To assess the evolution of body weight, serum micronutrient levels, and the effect of multivitamin supplementation during the first year after Roux-en-Y gastric bypass (RYGB). Methods: A retrospective longitudinal study including 101 patients who underwent RYGB between January 2022 and February 2024 at the Tâmega e Sousa Local Health Unit. Sociodemographic, clinical, anthropometric, and biochemical data were analyzed at four time points: preoperative, and at 3, 6, and 15 months postoperatively. Results: Of the 101 patients included, 89.1% were female. During the first postoperative year, body mass index decreased from 40.35 ± 3.15 to 25.36 ± 2.75 kg/m² (p < 0.001). Preoperative vitamin D deficiency was observed (47 ± 19 nmol/L). Significant increases were noted in iron (78 ± 32 to 88 ± 34 µg/dL), folate (6.6 ± 3.4 to 15.1 ± 7.1 ng/mL), vitamin D (47 ± 19 to 82 ± 27 nmol/L), and vitamin B12 (286 ± 130 to 374 ± 222 pg/mL), p < 0.001. Supplementation with RYGB-specific multivitamins was associated with more pronounced increases in vitamin D (39 ± 25 vs. 23 ± 23 nmol/L, p = 0.010), vitamin B12 (108 ± 236 vs. 9 ± 162 pg/mL, p = 0.017), and zinc (3.7 ± 16.9 vs. -7.6 ± 16.9 µg/dL, p = 0.006) compared to other supplements. The prevalence of hypertension, type 2 diabetes, and dyslipidemia decreased significantly (p < 0.001). Conclusions: RYGB was effective in promoting weight loss and improving comorbidities during the first year. Changes in micronutrient levels highlight the importance of monitoring and tailored multivitamin supplementation according to the surgical procedure.
Serdoura et al. (Tue,) conducted a observational in Adults undergoing Roux-en-Y gastric bypass surgery for obesity (n=101). Roux-en-Y gastric bypass with multivitamin supplementation vs. Other multivitamin supplements was evaluated on Change in body mass index and serum micronutrient levels after one year following Roux-en-Y gastric bypass (BMI decreased significantly (p < 0.001), p=<0.001). Roux-en-Y gastric bypass reduced BMI from 40.35 to 25.36 kg/m² and specific multivitamin supplementation increased vitamin D by 39 versus 23 nmol/L, vitamin B12 by 108 versus 9 pg/mL, and zinc by 3.7 versus -7.6 µg/dL at one year.