Multicenter analysis shows that males exhibit clearer clinical and MRI signs of inflammatory sacroiliitis in axial juvenile spondyloarthritis, suggesting a need for sex-based study designs.
In a large multicentre axJSpA cohort, males were significantly more likely to have clinical and MRI features of inflammatory sacroiliitis at the time axial disease was first diagnosed. Future trials in axJSpA should strongly consider stratification by sex in their design.
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Mayer et al. (2026) studied this question.
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