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March 6, 2026VaccineOpen Access

The epidemiological effect and cost-effectiveness of expanded age eligibility for recombinant zoster vaccination in England

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Authors

CKChu-Chang KuARAlicia RoselloJWJemma Walker

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Overview

Cost-effectiveness analysis evaluates expanded recombinant zoster vaccination for the elderly, suggesting potential healthcare savings.

Key Points

  • This analysis evaluates the feasibility and cost-effectiveness of expanding recombinant zoster vaccination to adults aged 80 and older in England.
  • Utilized a static cohort model to assess the impact of expanded vaccination.
  • Considered herpes zoster cases, severe outcomes, and associated healthcare costs.
  • Evaluated different eligibility scenarios for RZV among older adults.
  • Offering one dose of RZV to individuals aged 80 and above is likely to be cost-effective.
  • Two doses provide greater protection but are less cost-effective than one dose.
  • Vaccination of 60–69-year-olds is most efficient for quality of life benefits, while 80–89-year-olds minimize hospitalisation costs.

Cite This Study

Ku et al. (2026) studied this question.

synapsesocial.com/papers/69aa7160531e4c4a9ff5b7efhttps://doi.org/10.1016/j.vaccine.2026.128405
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Also Consider

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  1. 1Quality-Adjusted Life Expectancy Norms for the English Population2022 · 107 citations
  2. 2Final analysis of the ZOE-LTFU trial to 11 years post-vaccination: efficacy of the adjuvanted recombinant zoster vaccine against herpes zoster and related complications2025 · 25 citations
  3. 3Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom2008 · 288 citations
  4. 4Data Resource Profile: Hospital Episode Statistics Admitted Patient Care (HES APC)2017 · 784 citations
  5. 5Effectiveness of herpes zoster vaccination in an older United Kingdom population2018 · 51 citations