Key result
PPIs linked to increased CV risk regardless of concurrent clopidogrel use.
Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use.
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May warrant caution with PPI use in CV patients; challenges consensus that harm stems from clopidogrel interaction.
Controversy remains on whether the dual use of clopidogrel and proton-pump inhibitors (PPIs) affects clinical efficacy of clopidogrel.
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Charlot et al. (2010) studied this question. Proton-pump inhibitors are associated with increased cardiovascular risk regardless of concurrent clopidogrel use.
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