Efficacy and Safety of Vutrisiran in Patients with Hereditary Transthyretin-mediated Amyloidosis with Polyneuropathy: Analysis of the East Asian Subpopulation from HELIOS-A

Key Points

• This analysis aims to evaluate the efficacy and safety of vutrisiran in East Asian patients with hereditary transthyretin-mediated amyloidosis.
• Conducted a post hoc analysis of the HELIOS-A trial data
• Focused on the East Asian subpopulation
• Compared outcomes with the overall study population
• Vutrisiran showed similar outcomes in East Asian patients as in the overall population
• Indicated effective treatment with good tolerance