What question did this study set out to answer?

This research aims to define normal reference ranges for the Monocyte-to-HDL Ratio (MHR) and explore its links to inflammation and mortality across various diseases.

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March 7, 2026Open Access

From Reference Values to Clinical Impact: Monocyte-to-HDL Ratio (MHR) and Its Association with Inflammation and Mortality

Key Points

This research aims to define normal reference ranges for the Monocyte-to-HDL Ratio (MHR) and explore its links to inflammation and mortality across various diseases.
Establishment of normal MHR reference ranges
Assessment of MHR association with inflammatory diseases
Evaluation of links between MHR and mortality
Defined normal ranges for MHR
Established significant associations between MHR and several inflammatory diseases
Correlated higher MHR with increased mortality risk

Abstract

Traditional inflammatory biomarkers fail to capture the interplay between inflammation and lipid metabolism, key drivers of disease progression, especially in the context of cardiovascular-kidney-metabolic health 1. The novel Monocyte-to-HDL Ratio (MHR) biomarker reflects monocyte-driven inflammation and HDL’s anti-inflammatory properties 2. MHR's reference ranges and prognostic utility remain undefined. This study establishes normal MHR reference ranges and examines its association with various inflammatory diseases and associated mortality, including cardiovascular diseases (CVD), respiratory diseases (RD), kidney diseases (KD), diabetes mellitus (DM), and cancers.

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Cite This Study

Arabi et al. (Sun,) studied this question.

synapsesocial.com/papers/69abc0925af8044f7a4e9516 https://doi.org/https://doi.org/10.1016/j.waojou.2026.101318

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