Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema

F Palestra; M Bova; G Servillo; M Chetta; R Ciardi; P Candelaresi; M Tarsitano; C Suffritti; R Gualtierotti; S Miniello; A Ferrara; G Varricchi; R Cavallaro; V. Andreone; S Loffredo

doi:10.18176/jiaci.1146

March 4, 2026Journal of Investigational Allergology and Clinical ImmunologyOpen Access

Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema

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Key Points

This research aims to investigate the relationship between R-tPA-related angioedema and immune cell activation in ischemic stroke patients.
Observed immune cell behavior in patients receiving R-tPA treatment.
Analyzed the release of vasoactive mediators from peripheral blood mononuclear cells.
Assessed the association of immune dysregulation with angioedema incidence.
Indications of abnormal immune cell activation related to R-tPA treatment.
Increased levels of vasoactive mediators were noted in affected patients.
Suggests a link between immune dysregulation and angioedema in susceptible individuals.

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Implication

Observational data reveal immune dysregulation linked to angioedema in IS patients treated with R-tPA, suggesting new insights into its pathophysiology.

Abstract

These preliminary data suggest that R-tPA-related angioedema may result from abnormal immune cell activation, leading to increased release of vasoactive mediators. This immune dysregulation may contribute to the pathophysiology of angioedema in susceptible IS patients treated with R-tPA.

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Palestra et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e97d5 https://doi.org/10.18176/jiaci.1146

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Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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