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March 7, 20262 citationsOpen Access

Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2-Induced Ossification of the Annulus Fibrosus Cells.

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HSHisakazu ShitozawaRNRyo NakamichiAYAki Yoshida

Key Points

  • The research investigates how Piezo1 affects BMP2-induced ossification in annulus fibrosus cells under mechanical stress.
  • Assessment of Piezo1 function in annulus fibrosus cells
  • Analysis of BMP signaling pathway
  • Evaluation of calcineurin's role in suppressing osteogenic changes
  • Piezo1 inhibits BMP2-mediated ossification of annulus fibrosus cells
  • Calcineurin mediates the suppression of BMP signaling
  • Findings suggest potential therapeutic applications for intervertebral disc degeneration (IVDD)

Abstract

Piezo1 maintains AF cell homeostasis under mechanical stress by suppressing osteogenic changes via calcineurin-mediated inhibition of BMP signaling, which may represent a novel therapeutic target for IVDD.

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Cite This Study

Shitozawa et al. (2026) studied this question.

synapsesocial.com/papers/69abc0de5af8044f7a4e97edhttps://doi.org/10.1002/jsp2.70168
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The central mechanotransducer in osteoporosis pathogenesis and therapy2025 · 14 citations
  2. 2Piezo1 in hypertrophic chondrocytes regulates osteoclastogenesis in endochondral ossification2026
  3. 3Piezo1 protects against inflammatory bone loss via a unique Ca2+-independent mechanism in osteoclasts2025 · 14 citations
  4. 4PIEZO1 ‐Mediated Mechanotransduction in Craniofacial Biology2025 · 9 citations
  5. 5The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment2026 · 4 citations