⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

March 1, 2026Cell ReportsOpen Access

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Shixin Cui Nicole L. Batenburg Yan Coulombe Aruna Arumugam John R. Walker Sadaf Valeh Sheida Anja-Katrin Bielinsky M.C. Wahl Jean-Yves Masson Xudong Zhu

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research focuses on the function of ASCC3 helicase in unwinding DNA during replication stress.
Assessment of ASCC3 activity in DNA unwinding
Analysis of replication fork stability
Evaluation of stress-response pathways
ASCC3 effectively unwinds DNA at stalled replication forks
Enhanced replication stress response observed in the presence of ASCC3
Inhibition of ASCC3 leads to increased DNA damage

Implication

Research demonstrates the role of ASCC3 in managing DNA replication stress by unwinding stalled forks.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/69abc1015af8044f7a4e9aa4 https://doi.org/10.1016/j.celrep.2026.117051

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses2025
2Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responsesOriginal Research · 2026
3Human helicase geneSKI2Win the HLA class III region exhibits striking structural similarities to the yeast antiviral geneSKI2and to the human geneKIAA0052:emergence of a new gene familyOriginal Research · 1995 · 60 citations
4Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragilityOriginal Research · 2024 · 1 citations
5Cohesin reshapes replication fork contacts to aid fork slowing and reversalOriginal Research · 2026

More related papers

Spatial organization of supercoil dynamics during DNA replication2024
The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork2023
Profound synthetic lethality between SMARCAL1 and FANCM2024

More from Cell Reports

METTL4 interacts with histone methylation readers MRG1/2 to regulate alternative splicing and promote thermomorphogenesis in ArabidopsisTue,
An engineered probiotic for diagnosis and mucosal healing in inflammatory bowel diseaseTue,