Low-carbohydrate, high-fat diet is inversely associated with the triglyceride–glucose index: evidence from NHANES 1999–2018 | Synapse
March 7, 2026Open Access
Low-carbohydrate, high-fat diet is inversely associated with the triglyceride–glucose index: evidence from NHANES 1999–2018
Key Points
To explore the relationship between a low-carbohydrate, high-fat diet and the triglyceride-glucose index using NHANES data.
Analysis of NHANES data from 1999 to 2018
Assessment of dietary patterns focusing on carbohydrate and fat content
Evaluation of fasting triglyceride levels and triglyceride-glucose index
Lower triglyceride-glucose index was significantly associated with a low-carbohydrate, high-fat diet
The association was mainly driven by reduced fasting triglyceride levels
Abstract
A low-carbohydrate, high-fat diet was significantly associated with a lower triglyceride-glucose index; this association was primarily mediated by reductions in fasting triglyceride levels.