What does this research mean for the field?

Achiral benzoic acid appended helical polymers enable copper-catalyzed asymmetric Diels-Alder reactions and Michael additions with excellent enantioselectivity and recyclability. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to evaluate the performance of helical polyisocyanides in asymmetric reactions without stereogenic centers.

March 7, 2026Chemical Science1 citationsOpen Access

Achiral Benzoic Acid Appended Helical Polymers for Copper-catalyzed Asymmetric Diels-Alder Reaction and Michael Addition with Excellent Enantioselectivity and Recyclability

ZWZong-Quan WuJilin University QTQihui TiJilin University MMMing-Yang MoJilin University

Key Points

The aim is to evaluate the performance of helical polyisocyanides in asymmetric reactions without stereogenic centers.
Synthesis of helical polyisocyanides through asymmetric polymerization.
Utilization of chiral Pd(II) catalysts for the reactions.
Evaluation of enantioselectivity in Diels-Alder and Michael addition reactions.
Achieved excellent enantioselectivity in both asymmetric reactions.
Demonstrated effective recyclability of the helical polymers.

Abstract

One-handed helical polyisocyanides bearing achiral benzoic acid pendants were readily synthesized via the asymmetric polymerization of achiral isocyanides using chiral Pd(II) catalysts. Despite the inexistence of any stereogenic centers, these...

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