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Double-blind trial evaluates tetracosactide's impact on PDPH in postpartum women, suggesting limited efficacy.
( Br J Anaesth . 2025;135:148-154 doi: 10.1016/j.bja.2025.04.012) This randomized, double-blind, placebo-controlled clinical trial investigated whether tetracosactide, a synthetic analogue of adrenocorticotropic hormone (ACTH), could effectively treat postdural puncture headache (PDPH) in postpartum women who received neuraxial anesthesia. Conducted at 2 tertiary maternal hospitals in France, the study sought to evaluate if a single intravenous dose of tetracosactide could reduce the need for an epidural blood patch (EBP), the current gold-standard invasive treatment for PDPH.
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Dziadzko et al. (2026) studied this question.
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