What does this research mean for the field?

The strongest association between changes in esophageal pressure (∆Pes) and central venous pressure (∆CVP) is observed when using the total variation of CVP (∆CVPtot) calculated from the highest and lowest CVP values within a respiratory cycle. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to determine the best way to relate changes in esophageal pressure to variations in central venous pressure during mechanical ventilation.

March 7, 2026Journal of Clinical Monitoring and ComputingOpen Access

Relationship between esophageal and central venous pressure variation during respiratory activity: the best choice among four different methods to measure the amplitude of central venous pressure changes

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The study aims to determine the best way to relate changes in esophageal pressure to variations in central venous pressure during mechanical ventilation.
Analyzed CVP and Pes waveforms in 22 mechanically ventilated patients
Identified minimum, maximum, and average values for CVP per cardiac cycle
Calculated four types of central venous pressure variation per breath: ∆CVPmin, ∆CVPmax, ∆CVPavg, ∆CVPtot
Used linear mixed-effects models to assess associations between ∆Pes and each ∆CVP variant
All ∆CVP measures showed significant associations with ∆Pes
Strongest correlation was for ∆CVPtot, with marginal R² of 0.50 and conditional R² of 0.78
Using the median of consecutive breaths improved the association, increasing marginal R² from 0.60 to 0.70
∆CVPtot demonstrated the best relationship with ∆Pes when averaging data over multiple breaths

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Implication

Prospective analysis identifies the most accurate method for assessing central venous pressure changes during mechanical ventilation, indicating improved patient monitoring potential.

Cite This Study

Ogliari et al. (2026) studied this question.

synapsesocial.com/papers/69abc1a65af8044f7a4ea732 https://doi.org/10.1007/s10877-026-01425-z

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Implication

Prospective analysis identifies the most accurate method for assessing central venous pressure changes during mechanical ventilation, indicating improved patient monitoring potential.

Relationship between esophageal and central venous pressure variation during respiratory activity: the best choice among four different methods to measure the amplitude of central venous pressure changes

Key Points

Discussion

Implication

Cite This Study

Relationship between esophageal and central venous pressure variation during respiratory activity: the best choice among four different methods to measure the amplitude of central venous pressure changes

Key Points

Discussion

Implication

Cite This Study

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