This conceptual framework categorizes mechanisms of action in digital therapeutics, suggesting pathways to enhance effectiveness.
Digital therapeutics (DTx) are increasingly established, yet their mechanisms of action (MoA) remain underexplored. This article defines and categorizes DTx MoA through a novel conceptual framework, distinguishing them from conventional treatments. We specifically conceptualize therapeutic elements, cognitive-affective and behavioral changes, and segment the notion of “dose” into distinct categories. This actionable framework provides a systematic basis for enhancing DTx research, design, and clinical effectiveness.
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Schmidt et al. (2026) studied this question.
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