Locus-specific human endogenous retrovirus ERVK18 expression indicates an inflamed microenvironment and favorable immunotherapy outcome in small cell lung cancer

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Key Points

This research aims to determine the significance of ERVK18 expression in predicting immunotherapy outcomes in small cell lung cancer (SCLC).
Analyzed ERVK18 expression levels in samples from SCLC patients.
Correlated expression data with markers of inflammation.
Assessed the relationship between ERVK18 levels and immunotherapy responses.
Higher ERVK18 expression correlates with an inflamed microenvironment.
Patients with elevated ERVK18 show improved responses to immunotherapy.
Indications of a favorable prognosis were linked to ERVK18 levels.

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Elevated ERVK18 expression indicates favorable immunotherapy outcomes in small cell lung cancer, suggesting a link to inflammation.

Elevated expression of ERVK18 represents inflamed microenvironment and indicates favorable immunochemotherapy prognosis of patients in SCLC.

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Wu et al. (2026) studied this question.

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