Microwave Irradation Outperforms Traditional Methods: Improved Synthesis of Azidobenzohydrazide Schiff Bases

An efficient synthesis of organic compounds including Azidobenzohydrazide derivatives, is important for industrial, agricultural, and medical applications. Synthesizing bioactive compounds need various procedures, however, simple methods are highly preferred. In the present study, four different synthetic techniques, including stirring, reflux, ultrasonic, and, microwave irradiation, were employed to synthesize series of azidobenzohydrazide derivatives. Each procedure take place with their optimum conditions to yield highest and purest products. In this study, we aimed to compare different synthetic approaches, and highlighting the most effective one among the others. The results showed that the microwave irradiation is the most efficient approach among the others, since it’s faster and more product yields. This comparative analysis highlights the importance of microwave techniques over the conventional methods, providing insights into how to optimize synthesis procedures for these significant chemicals.