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March 7, 2026Journal of Dermatological Treatment2 citationsOpen Access

Clinical characteristics, effectiveness, safety, and predictors of PASI75/90 responses to IL-17 biologics in psoriasis involving special sites: a large real-world cohort study revealing treatment response heterogeneity

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FHFengming HuXXXinglong XiongYLYujie Lai

Key Points

  • This research aims to evaluate the effectiveness and safety of IL-17 biologics in treating psoriasis, focusing on special site involvement.
  • Real-world cohort study design
  • Assessment of treatment effectiveness using PASI75/90 metrics
  • Comparison of clinical characteristics such as BMI and disease severity indices
  • Analysis of predictors influencing treatment response
  • IL-17 inhibitors demonstrate substantial efficacy in treating psoriasis at special sites
  • Safety profile of IL-17 inhibitors is favorable
  • Treatment response varies significantly based on baseline characteristics like BMI and disease severity indices

Abstract

Overall, IL-17 inhibitors show substantial efficacy and a favorable safety profile for psoriasis in special sites, with treatment response variability influenced primarily by baseline clinical characteristics such as BMI and disease severity indices.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69abc2555af8044f7a4ebcdahttps://doi.org/10.1080/09546634.2026.2633794
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