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March 7, 2026BMC GastroenterologyOpen Access

Profile and diagnostic value of N6-methyladenosine-related mRNA regulators in colorectal adenoma and colorectal cancer

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Authors

WWWei WangXZXiaohui ZhangMWMin Wang

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Overview

Analyses identify diagnostic m6A regulators in colorectal adenoma and cancer, suggesting valuable clinical implications.

Key Points

  • This research aims to explore the role of N6-methyladenosine regulators in colorectal adenoma and cancer and assess their diagnostic value.
  • Analyzed gene expression profiles from GEO datasets.
  • Identified differentially expressed m6A regulators using clustering techniques.
  • Conducted gene set enrichment analysis (GSEA) on differentially expressed genes.
  • Utilized LASSO regression and SVM-RFE to identify significant m6A regulators.
  • Evaluated the diagnostic value of hub genes using ROC analysis.
  • Identified 15 DE-m6A regulators in colorectal adenoma (CRA) and 13 in colorectal cancer (CRC).
  • Found two distinct m6A patterns for CRA and CRC based on DE-m6A regulators.
  • Enrichment analysis revealed DEGs related to ribosomal components and mitochondrial function.
  • Five hub genes were linked to CRA, while none were found significant for CRC.
  • YTHDF1 and HNRNPA2B1 showed high diagnostic efficacy for CRA and CRC respectively.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69abc2615af8044f7a4ebe75https://doi.org/10.1186/s12876-026-04722-8
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Also Consider

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  1. 1Comprehensive analysis of m6A RNA methylation regulators for prognostic risk stratification and immune microenvironment characterization in colorectal cancer2026
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  4. 4Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer2024 · 6 citations
  5. 5m6A RNA Modification in Colorectal Cancer: Regulatory Roles, Oncogenic Signaling, and Metabolic Pathways2026