Macrophages are critical components of the innate immune system and play a pivotal role in the hematological tumor microenvironment. Their metabolic reprogramming can exert dual effects, either promoting or suppressing tumor progression. Significant advances have been made in the understanding of the functions of macrophages and their metabolic regulatory mechanisms. However, there are various uncertainties and challenges regarding the specific metabolic pathways of macrophages in different hematological malignancies and their interactions. This review summarized the recent research progress on macrophage metabolic reprogramming in hematological tumors, explored potential targeted therapeutic strategies based on macrophage metabolic reprogramming, and provided new research directions and clinical insights for the immunotherapy of hematological malignancies.
Li et al. (2026) studied this question.