What question did this study set out to answer?

To explore the association of albumin infusion with outcomes in pediatric sepsis and septic shock.

March 8, 2026Pediatric Critical Care Medicine0 citations

Association of Albumin Infusion With Differential Response in Pediatric Sepsis and Septic Shock: Retrospective Analysis Using a U.S. Multicenter 2012–2018 Dataset

CLCheolmin Matthew LeeNorthwestern University MAMihir R. Atreya TBTellen D. Bennett

Key Points

To explore the association of albumin infusion with outcomes in pediatric sepsis and septic shock.
Retrospective analysis of patient data from a U.S. multicenter dataset
Analysis period from 2012 to 2018
Comparison of outcomes between children with septic shock and those without shock
Early albumin administration improved outcomes in children with septic shock
No significant improvement noted in children without septic shock
Findings underscore the need for targeted interventions based on clinical characteristics

Abstract

Early albumin administration was associated with improved outcomes in children with septic shock, but not in those without shock. These results highlight the importance of considering clinical heterogeneity, such as the presence of shock, in identifying treatment-responsive subgroups and enabling more targeted interventions in pediatric sepsis. Further prospective validation is warranted.

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