Scoping review highlights biological activity and delivery systems of recombinant amelogenin for periodontal regeneration, suggesting further studies are needed.
Recombinant amelogenin shows consistent preclinical activity supporting its biological plausibility as a regenerative agent. However, evidence remains largely preclinical and heterogeneous. Future studies should employ standardised models, optimised delivery systems, and direct comparisons with established therapies to clarify its translational potential in periodontal regeneration.
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Luo et al. (2026) studied this question.
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