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March 2, 2026Protein and Peptide Letters

Irisin Mitigates Myocardial Hypoxia/Reoxygenation Injury by Preserving Mitochondrial Redox Homeostasis via the UCP2-SOD2 Axis

Xu Yang Huanqing Liu Shuang Liu Peng Wu Rui Wang You Li Xing Wang Qiuyu Cao Lei Duan Ruobai Qiao Hao Tang Zhen Wang

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Key Points

The aim is to explore how Irisin protects cardiomyocytes during hypoxia/reoxygenation stress.
Examined the protective effects of Irisin on cardiomyocytes during hypoxia/reoxygenation injury.
Analyzed the role of UCP2 in mediating these protective effects.
Irisin effectively preserved cellular health in cardiomyocytes under hypoxic conditions.
The UCP2 component was crucial in the protective mechanism against oxidative stress.

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Implication

Irisin mitigates H/R injury in cardiomyocytes, suggesting it may support mitochondrial health.

Abstract

Irisin protects cardiomyocytes against H/R injury primarily via a novel UCP2-SOD2 axis.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69acc59c32b0ef16a40501ab https://doi.org/10.2174/0109298665445300260128064859

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