Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy.

Yawei Cheng; Gengliang Li; Yang Li; Yugang Ma; Yujie Xia; Chunye Zhang; X Wang

doi:10.1093/jpp/rgag014

March 5, 2026

Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy.

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Key Points

To evaluate the effects of oleanolic acid on podocyte injury related to diabetic nephropathy.
Assessing the impact of oleanolic acid on podocytes under high glucose conditions.
Measuring autophagy levels to determine the mechanism of action.
Investigating potential therapeutic strategies involving traditional Chinese medicine.
Oleanolic acid significantly activates autophagy in podocytes.
Reduction of high glucose-induced podocyte injury is observed.
Findings support the use of TCM compounds in diabetic nephropathy treatment.

Implication

Oleanolic acid improves podocyte injury by increasing autophagy in diabetic nephropathy, suggesting potential for TCM therapies.

Abstract

Oleanolic acid alleviates high glucose-induced podocyte injury by robustly activating autophagy, underscoring its potential as a sustainable therapeutic strategy for DN, along with other active compounds derived from TCM.

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Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69acc59c32b0ef16a40501fa https://doi.org/10.1093/jpp/rgag014

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Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy.

Key Points

Implication

Abstract

Discussion

Cite This Study

Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy.

Key Points

Implication

Abstract

Discussion

Cite This Study

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