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March 8, 2026Scientific ReportsOpen Access

The network pharmacology prediction and experiment validation of Astragalus membranaceus for alleviating silicosis fibrosis via decreasing MMP9 and EGFR expression

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Authors

AYAnning YangXLXiaoyu LuoYGYi Guo

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Overview

Bioinformatics reveals molecular docking insights for Astragalus membranaceus components in silicosis fibrosis, suggesting a role for isorhamnetin.

Key Points

  • This research investigates how Astragalus membranaceus can alleviate silicosis fibrosis through its molecular mechanisms.
  • Used bioinformatics to identify active ingredients and targets of Astragalus membranaceus
  • Analyzed protein-protein interactions and pathways using Cytoscape
  • Conducted molecular docking studies and in vitro assays to validate findings
  • Identified 8 active ingredients and 236 AM targets related to silicosis
  • Confirmed the roles of isorhamnetin and other key ingredients in downregulating fibrosis
  • Molecular docking showed significant interaction of AM components with silicosis-related proteins

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69acc5bd32b0ef16a4050764https://doi.org/10.1038/s41598-026-42544-6
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