Results demonstrate tumor-associated macrophages regulate cytokines and extracellular matrix in breast cancer, suggesting implications for immunosuppression.
The results demonstrated the existence of a single regulatory axis, "TAMs - cytokines - ECM", which determined the development of the immunosuppressive and invasive BC microenvironment. The predominance of CD163+ Mj against the background of increased levels of IL-10, SPP1, and COX-2 was associated with a high degree of BC malignancy.
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Pavlova et al. (2026) studied this question.
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