Folic acid protects endothelial cells dysfunction against T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway

Lei Hong; Xinqi Lou; Yingjie Zha; Xuejie Fu; Tuanjie Che; Shigang Qiao; Chen Wang; Jianzhong An

doi:10.1039/d5fo04381f

January 1, 2026Food & Function

Folic acid protects endothelial cells dysfunction against T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway

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Key Points

This research aims to investigate the protective effects of folic acid on endothelial cells against ferroptosis induced by type 2 diabetes mellitus (T2DM).
Investigated the effects of folic acid on endothelial cell dysfunction in T2DM models.
Analyzed the activation of the SIRT6/NRF2/GPX4 signaling pathway.
Assessed the impact on ferroptosis and cardiovascular complications.
Folic acid showed protective effects against T2DM-induced endothelial dysfunction.
Activation of the SIRT6/NRF2/GPX4 signaling pathway was enhanced.
Reduced markers of ferroptosis were observed in endothelial cells treated with folic acid.

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Implication

Folic acid mitigates endothelial cell dysfunction and cardiovascular complications in T2DM by activating key signaling pathways, suggesting therapeutic potential.

Abstract

Cardiovascular complications associated with type 2 diabetes mellitus (T2DM) pose a serious threat to human health. Folic acid deficiency is associated with various diseases, including atherosclerosis. However, it remains unclear...

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69acc5bd32b0ef16a40508e7 https://doi.org/10.1039/d5fo04381f

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Folic acid protects endothelial cells dysfunction against T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Folic acid protects endothelial cells dysfunction against T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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