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Neuropsychiatric disorders can be predicted by the principal component built from inflammatory biomarkers (IL-1β, IL-10, IL-18, and CRP). In contrast, PC_IR has a lower predictive value for the neuropsychiatric disorders compared with PC_Inflam. These results indicated the significant role of inflammation in the main symptoms of LC.
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Al-Jassas et al. (2026) studied this question.