Psoriatic dactylitis: the association with HLA genetic susceptibility markers

Fadi Kharouf; Virginia Carrizo Abarza; Pankti Mehta; Shangyi Gao; Darshini Ganatra; Daniel Pereira; Richard J Cook; Denis Poddubnyy; Dafna D Gladman; Vinod Chandran

doi:10.1016/j.ard.2026.02.011

March 1, 2026Annals of the Rheumatic DiseasesOpen Access

Psoriatic dactylitis: the association with HLA genetic susceptibility markers

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Key Points

The research aims to explore the genetic factors linked to psoriatic arthritis-related dactylitis.
Assessment of HLA-B*27 and HLA-C*02 genetic markers in relation to dactylitis.
Analysis of the haplotype effects on symptom resolution and severity.
HLA-B*27 and HLA-C*02 are linked with susceptibility to dactylitis in psoriatic arthritis.
The HLA-B*27 allele may affect the resolution of tender dactylitis.

Implication

Genetic markers associated with dactylitis severity in psoriatic arthritis imply future treatment directions.

Abstract

HLA-B*27 and -C*02 and the HLA-B*27/C*02 haplotype are associated with PsA dactylitis. HLA-B*27 may also influence the resolution of tender dactylitis. These alleles are thus associated with PsA dactylitis susceptibility and severity; replication studies are required.

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Cite This Study

Kharouf et al. (2026) studied this question.

synapsesocial.com/papers/69ada804bc08abd80d5bb2ca https://doi.org/10.1016/j.ard.2026.02.011

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Psoriatic dactylitis: the association with HLA genetic susceptibility markers

Key Points

Implication

Abstract

Discussion

Cite This Study

Psoriatic dactylitis: the association with HLA genetic susceptibility markers

Key Points

Implication

Abstract

Discussion

Cite This Study

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