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This study aims to investigate the relationship between immune cell infiltration and prognosis in obstructive colorectal cancer (OCRC).

March 8, 20260 citations

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Increased Infiltration of CD4+, CD8+, and CD68+ Cells at the Invasive Front Is Associated With Favorable Prognosis in Obstructive Colorectal Cancer: A Retrospective Observational Study.

GTGoro TakahashiYamaha (Japan)SSSeiichi ShinjiTokyo Metropolitan Institute of Gerontology TIToshiyuki IshiwataTokyo Metropolitan Institute of Gerontology

Key Points

This study aims to investigate the relationship between immune cell infiltration and prognosis in obstructive colorectal cancer (OCRC).
Retrospective observational study design
Assessment of immune cell types (CD4+, CD8+, CD68+) at the invasive front
Data analysis focused on prognosis outcomes in OCRC patients
High infiltration of CD4+, CD8+, and CD68+ cells correlates with better prognosis
The invasive front is a significant site for immune interaction with the tumor
Findings suggest potential for improved clinical management based on immune cell presence

Abstract

High immune cell infiltration at the invasive front was associated with favorable prognosis, even in OCRC. As the invasive front represents the interface between host and tumor, assessment of the tumor immune microenvironment at this site may refine risk stratification and optimize clinical management in OCRC patients.

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Increased Infiltration of CD4+, CD8+, and CD68+ Cells at the Invasive Front Is Associated With Favorable Prognosis in Obstructive Colorectal Cancer: A Retrospective Observational Study.

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