What does this research mean for the field?

Elevated homocysteine (Hcy), elevated low-density lipoprotein cholesterol (LDL-C), prolonged onset-to-treatment time (ODT), and longer procedure duration independently predict short-term neurological deterioration in patients with acute ischemic stroke due to anterior circulation large vessel occlusion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify independent risk factors contributing to neurological deterioration in acute ischemic stroke due to large vessel occlusion.

March 8, 2026Clinical Neuropharmacology0 citations

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Risk Factors for Symptom Aggravation in Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion

SLShugai LiuTaiyuan Central Hospital TPTianqiang PuTaiyuan Central Hospital QRQiang RanTaiyuan Central Hospital

Key Points

To identify independent risk factors contributing to neurological deterioration in acute ischemic stroke due to large vessel occlusion.
Observational analysis of stroke patients
Assessment of homocysteine (Hcy) and LDL cholesterol (LDL-C) levels
Measurement of onset-to-door time (ODT) and procedure duration
Elevated Hcy levels significantly predict neurological deterioration
High LDL-C levels are associated with increased risk of short-term worsening
Prolonged ODT and procedure duration independently linked to neurological decline

Abstract

Elevated Hcy, elevated LDL-C, and prolonged ODT and procedure duration independently predict short-term neurological deterioration.

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Risk Factors for Symptom Aggravation in Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion

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Abstract

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