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Synapse
March 8, 2026Communications Medicine0 citationsOpen Access

Patient-specific alterations in blood plasma cfRNA profiles enable accurate classification of cancer patients and controls

AMAnnelien MorlionPDPhilippe DecruyenaereKSKathleen Schoofs

Key Points

  • The research aims to explore how cell-free RNA profiles can differentiate cancer patients from controls.
  • Analyzed blood plasma samples for cfRNA alterations
  • Classified samples based on identified RNA profiles
  • Compared profiles between cancer patients and controls
  • Observed significant variability in cfRNA profiles among cancer patients
  • Identified specific RNA patterns that predict cancer presence
  • Demonstrated potential for using cfRNA as a classification biomarker

Abstract

Our findings demonstrate substantial heterogeneity in cell-free RNA alterations among cancer patients and propose that patient-specific changes can be exploited for classification.

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Cite This Study

Morlion et al. (2026) studied this question.

synapsesocial.com/papers/69ada8a1bc08abd80d5bbc11https://doi.org/10.1038/s43856-026-01507-8
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