Prognostic stratification in hepatocellular carcinoma using a telomerase-related lncRNA signature derived from TCGA database

Key Points

• The aim is to utilize a telomerase-related lncRNA signature for prognostic stratification in hepatocellular carcinoma (HCC).
• Derived the 4-TRLs signature from The Cancer Genome Atlas (TCGA) database.
• Analyzed the correlation of lncRNAs with immune activity and drug response.
• Evaluated the role of lncRNAs in tumor progression and microenvironment.
• 4-TRLs signature effectively stratifies HCC patients' prognosis.
• Identified lncRNAs are linked to immune modulation.
• The findings suggest implications for precision oncology in HCC treatment.

Abstract