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Uncovers unique traits of HER2-low breast cancer in an Arab cohort, suggesting therapeutic over prognostic value.
In this large, ethnically homogenous Saudi cohort, HER2-low breast cancer represents a distinct molecular and clinicopathological subtype with luminal like features, yet no prognostic advantage. These findings reinforce the therapeutic, rather than prognostic, significance of HER2-low status, highlighting its relevance in targeted antibody-drug conjugate-based therapies rather than influencing baseline risk stratification.
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Siraj et al. (2026) studied this question.
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