The rapid rise of illnesses that are resistant to antibiotics is a major worldwide health problem that could kill millions of people every year. Many harmful bacteria can now cause serious and often deadly infections that are becoming harder to cure with regular medications. This worrying trend makes clear the need for new and effective ways to fight germs right away. Silver nanoparticles (AgNPs) are getting much interest as a new option because they are powerful and diverse antibacterial agents that work on a wide range of bacteria. Because of their unique physical and chemical properties that rely on their size, AgNPs have amazing biological interactions. These properties come from quantum confinement and improved surface-to-volume ratios. There are physical, chemical, and biological methods to synthesize these nanoparticles; each one changes their shape, stability, and bioactivity. When AgNPs come into contact with microbial cells, they cause structural and functional problems that lead to cell death. These problems include damaging membranes, denaturing proteins, and interfering with DNA replication. Ongoing improvements in the regulated synthesis, accurate characterization, and mechanistic comprehension of AgNPs are enhancing their therapeutic potential, facilitating their optimal utilization in healthcare, biomedicine, and infection control.
Jain et al. (2026) studied this question.