A 12-week personalised exercise and self-management programme significantly reduced systolic blood pressure by 4.7 mmHg compared to usual care in people with multimorbidity.
RCT (n=228)
Single-blind
1:1 allocation ratio using permuted blocks
Sí
Does a 12-week personalised exercise therapy and self-management support programme improve blood pressure and biomarkers of inflammation, glycaemic control, and lipids in adults with multimorbidity?
A 12-week personalised exercise and self-management programme significantly reduces systolic blood pressure in adults with multimorbidity, supporting its use as a non-pharmacological adjunct.
Estimación del efecto: Mean difference -4.7 mmHg (95% CI -8.8 to -0.6)
Background: Multimorbidity is linked to systemic low-grade inflammation, poor glycaemic control, dyslipidaemia, and hypertension, yet evidence on effective interventions is limited. We evaluated the impact of a 12-week personalised exercise therapy and self-management support programme, in addition to usual care, on these outcomes in individuals with multimorbidity. Methods: This was a pre-planned secondary analysis of the MOBILIZE multicentre randomised controlled trial (NCT04645732). Participants (n = 228) had at least two of the following conditions: knee/hip osteoarthritis, chronic obstructive pulmonary disease, heart disease, hypertension, type 2 diabetes, or depression. The intervention included 24 supervised 60-minute group-based exercise sessions and 24 self-management sessions over 12 weeks. Outcomes were assessed at baseline and 4 months, including interleukin-1 receptor antagonist (IL-1ra), high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), glycated Hemoglobin (HbA1c), fasting glucose, insulin, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), triglycerides, and blood pressure. Results: Compared to usual care, the intervention group shows a statistically significant reduction in systolic blood pressure (mean difference: −4.7 mmHg, 95% CI: −8.8 to −0.6). No significant between-group differences are observed for other biomarkers, although favouring the intervention. Sensitivity analyses—excluding participants with low adherence, those receiving supervised exercise in the control group, or undergoing surgery—support the primary findings. Conclusions: A 12-week personalised exercise and self-management programme reduces systolic blood pressure in people with multimorbidity. These findings support incorporating exercise therapy into multimorbidity care guidelines as a non-pharmacological adjunct.
Bricca et al. (Fri,) conducted a rct in Multimorbidity (n=228). Exercise therapy and self-management support programme vs. Usual care was evaluated on Change in systolic blood pressure at 4 months (Mean difference -4.7 mmHg, 95% CI -8.8 to -0.6). A 12-week personalised exercise and self-management programme significantly reduced systolic blood pressure by 4.7 mmHg compared to usual care in people with multimorbidity.