IgG4 on the dance floor: Partners swapped by Fab-arm exchange

Key Points

• This research aims to explore the processes and implications of Fab-arm exchange in IgG4 antibodies.
• Conducted proteomic analysis of circulating IgG4 antibodies.
• Identified occurrence and extent of Fab-arm exchange.
• Characterized the bispecific antibody repertoire generated.
• Nearly all circulating human IgG4 undergoes Fab-arm exchange.
• A vast bispecific antibody repertoire is created through this process.