Key result
Higher Lp(a) linearly predicts incident ASCVD across racial groups in primary and secondary prevention.
Why the study?
Do lipoprotein(a) concentrations predict incident atherosclerotic cardiovascular disease in middle-aged adults within primary and secondary prevention contexts?
Do lipoprotein(a) concentrations predict incident atherosclerotic cardiovascular disease in middle-aged adults within primary and secondary prevention contexts?
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“In this context, Lp(a) and apo B serve as important tools for risk refinement for South Asian patients in particular, helping clinicians identify residual atherogenic risk that may be underestimated by a standard lipid panel alone.”
Lipoprotein(a) concentrations predict incident ASCVD with a linear risk gradient across primary and secondary prevention contexts, showing similar risk across racial subgroups despite varying baseline concentrations.
Lipoprotein(a) concentrations predict incident ASCVD among middle-aged adults within primary and secondary prevention contexts, with a linear risk gradient across the distribution. Concentrations are variable across racial subgroups, but the associated risk appears similar.
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Patel et al. (2020) studied this question. Lipoprotein(a) concentrations linearly predict incident atherosclerotic cardiovascular disease across racial subgroups in both primary and secondary prevention contexts.
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