Key result
7-Ketocholesterol accumulation drives inflammation, mitochondrial dysfunction, and cell death during chronic oxidative stress.
This review highlights the pathophysiological mechanisms of 7-Ketocholesterol and its metabolites in diseases associated with chronic oxidative stress, suggesting potential targets for future intervention strategies.
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Dias et al. (2026) conducted a review in Diseases associated with chronic oxidative stress. 7-Ketocholesterol and hydroxylated 7-Ketocholesterol was evaluated. 7-Ketocholesterol and its hydroxylated metabolites accumulate during oxidative stress, promoting inflammation, mitochondrial dysfunction, and cell death in diseases associated with chronic oxidative stress.
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