Proximity extension assay-based serum proteomic profiling identifies shared protein signatures in hypermobile Ehlers–Danlos syndrome and hypermobility spectrum disorders

This targeted serum proteomic analysis identified overlapping protein expression changes in hEDS and HSD relative to controls, while revealing no detectable differences between the two conditions. These findings suggest the presence of shared molecular features across the hEDS/HSD spectrum and identify a set of candidate circulating proteins that warrant further investigation and independent validation in larger, well-characterized cohorts.