This research identifies how methylation inhibits germ cell maturation in humans, suggesting potential impacts on fertility.
We identified specific BOLL promoter CpGs that are hypermethylated in HS and associated with reduced gene expression. These findings suggest that promoter methylation may contribute to BOLL silencing and impaired spermatid differentiation, supporting its regulatory role in human spermiogenesis.
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Lin et al. (2026) studied this question.
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