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March 10, 2026Clinical and Experimental Medicine0 citationsOpen Access

Consensus on CLL/SLL Management in Tuscany for 2025

Real‑life diagnostic and therapeutic approach to CLL/SLL in tuscany: the 2025 consensus

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Authors

MDMaria D’AmatoCRChiara Maria RapollaEBEdoardo Benedetti

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Overview

Experts propose an updated diagnostic and therapeutic approach for CLL/SLL, suggesting enhanced risk stratification and treatment strategies.

Key Points

  • To propose an updated diagnostic and therapeutic framework for CLL/SLL management incorporating new therapeutic agents and risk factors.
  • Expert panel consensus formulation
  • Integration of genomic and somatic factors into treatment decisions
  • Recommendation for routine FISH and TP53 testing
  • Emphasis on cardio-oncological screening
  • Tailored treatment selection based on age and genetic risk
  • Confirmed abandonment of chemoimmunotherapy for targeted agents
  • Validated utility of abdominal and superficial lymph node ultrasound for diagnosis
  • Promoted the safe use of zanubrutinib, acalabrutinib, and venetoclax
  • Outlined management strategies for high-risk scenarios like Richter transformation

Cite This Study

D’Amato et al. (2026) studied this question.

synapsesocial.com/papers/69af949670916d39fea4ba09https://doi.org/10.1007/s10238-026-02100-y
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