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March 10, 2026Alcoholism & Drug Abuse Weekly0 citations

Widespread Contraindicated Psychotropic Medication Use Among Youth

Contraindicated psychotropic medication use widespread among youth

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AKAlison Knopf

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Overview

Researchers reveal increasing drug-drug interactions in youth using psychotropic medications, suggesting a need for safety studies.

Key Points

  • To assess trends in psychotropic medication use and evaluate the prevalence of drug-drug interactions among youth.
  • Analyzed data from the US National Health and Nutrition Examination Survey (NHANES) from 2001 to 2020.
  • Stratified participants into age groups: children (6-11 years), adolescents (12-19 years), young adults (20-24 years).
  • Assessed psychotropic medication use and polypharmacy based on reported use in the past 30 days.
  • Psychotropic medication use rose from 5.3% (2001-2004) to 8.3% (2017-2020), primarily due to stimulants.
  • Polypharmacy prevalence increased from 1.8% to 3.3% during the same period.
  • 26% of users were exposed to potential contraindicated or major drug-drug interactions, mainly from antipsychotics and antidepressants.
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Alison Knopf (2026) studied this question.

synapsesocial.com/papers/69af94e870916d39fea4bebahttps://doi.org/10.1002/adaw.34830
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