Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 10, 2026ChemistrySelect

Coumarin Derivatives as Potent Urease Inhibitors: In Vitro Evaluation, and Molecular Docking Studies

View Full Paper
Ask AI
Bookmark
Share

Authors

MNMuhammad Shahid NazirGovernment College University, FaisalabadMAMatloob AhmadGovernment College University, FaisalabadSZSumera ZaibUniversity of Central Punjab

Discussion

Loading...

Member takes

Implication

Evaluation reveals coumarin derivatives inhibit urease effectively, indicating potential clinical applications.

Key Points

  • This research aims to evaluate coumarin-derived compounds as urease inhibitors and analyze their binding interactions.
  • Synthesis of coumarin-derived N-arylacetamides
  • Biological evaluation for urease inhibition
  • Spectroscopic analysis of compounds
  • Structure-activity relationship analysis
  • Molecular docking studies to assess binding interactions
  • The most potent inhibitor was compound 5c with an IC50 of 0.92 µM, outperforming thiourea.
  • A varied degree of urease inhibition was observed across different derivatives, with IC50 values ranging from 0.92 to 11.9 µM.
  • Molecular docking confirmed strong binding interactions between compound 5c and urease.
  • Compound 5c exhibited favorable ADME properties but raised potential toxicity concerns due to its coumarin moiety.

Cite This Study

Nazir et al. (2026) studied this question.

synapsesocial.com/papers/69af94e870916d39fea4bf53https://doi.org/10.1002/slct.202504607
View Full Paper
Ask AI
Bookmark
Share