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March 10, 2026Discover OncologyOpen Access

The combination therapy with venetoclax in therapeutic strategy of acute lymphoblastic leukemia

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Authors

MSMobina Nakhaei ShamahmoodMYMohammad Javad YousefiAMAbolfazl Miri

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Overview

Narrative review evaluates the efficacy of venetoclax combinations in treating acute lymphoblastic leukemia, suggesting promising therapeutic strategies.

Key Points

  • To review the efficacy of venetoclax-based combination therapies in acute lymphoblastic leukemia (ALL).
  • Summarized preclinical and clinical studies evaluating venetoclax combinations.
  • Emphasized mechanistic rationale behind combination therapies.
  • Critically discussed therapeutic implications of findings.
  • Combination with hypomethylating agents, monoclonal antibodies, and kinase inhibitors enhances leukemia treatment.
  • Venetoclax showed improved antileukemic activity in various ALL subtypes.
  • Current evidence indicates potential but highlights the need for randomized trials.

Cite This Study

Shamahmood et al. (2026) studied this question.

synapsesocial.com/papers/69af950a70916d39fea4c2f5https://doi.org/10.1007/s12672-026-04593-1
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