Synthesis of Hetero‐annulated Dibenzothiophene Analogues via ZnBr 2 ‐Mediated Domino Reaction of 2/3‐Bromomethylbenzo b Thiophene With Heteroarenes

Key Points

• The research aims to synthesize hetero-annulated dibenzothiophenes through a domino reaction involving specific substrates and catalysts.
• Conducted domino reactions of 2-acetyl 3-bromomethyl benzo[b]thiophene with heteroarenes.
• Utilized ZnBr2 as a catalyst in 1,2-DCE solvent at room temperature and elevated temperatures.
• Examined a variety of thiophenes and representative benzo-heterocycles in the reactions.
• Produced various types of hetero-annulated dibenzothiophenes in moderate yields.
• Successfully performed reactions at room temperature and 80°C with diverse heteroarenes.
• Achieved good results with thiophenes and significant benzo-heterocycles like indole and benzo[b]furan.